The history of Domus Bothnica goes all the way back to the founding of the Student Union of the Vaasa Business School, when the first thoughts of a Student Union premises rose up. The project progressed throughout the years, sometimes with greater pace, sometimes hardly at all. At various points of the project, the house has been visioned at the Leipätehdas facilities in the city center as well as by the railway station on Hovioikeudenpuistikko.

A Systematic fundraising was started in 1983 by founding a development fund. Growing the capital of the fund was based on membership fees of the Student Union, income from the Student Union's businesses and fundraisers. After some twenty years of fundraising the project to build the house started at full speed. The City of Vaasa granted the Student Union a reservation on the plot at Yliopistonranta in 2005. After an architect competition, the Aitoaho & Viljanen was chosen as the architect firm for the Student Union house. The following year the development fund was transferred to a real estate company Kiinteistöosakeyhtiö Vaasan ylioppilastalo, which had been founded to take care of the project.

Following a naming competition among the Student Union members, Domus Bothnica - the Student Union House of Vaasa was chosen as the name of the building. The project was accomplished together with Palosaaren Yrityskeskus Oy, owned by the City of Vaasa. Building the house was begun in august 2007. The foundation was masoned by the Mayor of Vaasa Markku Lumio, the Rector of the University of Vaasa Matti Jakobson and the Chairperson of the Board of the Student Union, Lauri Vaisto.

The building was at its top height in april, 2008. It was finally ready to enter service by the end of the summer. The Student Union and the companies took the facilities into use during the autumn of 2008, and the official inauguration was held on september the 24th 2008, after which its facilities as well as the Wärtsilä Hall and ABB Sauna have seen extensive use.